Photoinduced LMCT-Catalyzed Regioselective C(sp 3 )–H Functionalization of Boronates via a 1,2-Boryl Migration Pathway
Abstract
Radical-initiated 1,2-boryl migration has emerged as an efficient strategy for the synthesis of versatile functionalized organoboron compounds. However, this transformation typically requires the use of prefunctionalized boronates. Herein, we report a mild photoinduced ligand-to-metal charge transfer (LMCT) protocol for the C(sp 3 )–H alkylation and arylation of unactivated alkyl boronates. This method enables a step-economical route to diverse functionalized boronates with good regioselectivity. Mechanistic studies suggest that the reaction proceeds through a sequential hydrogen atom transfer and 1,2-boryl migration pathway.
Fields of Study & Subjects
Catalytic C–H Functionalization Methods
Organoboron and organosilicon chemistry
Radical Photochemical Reactions
Publication details
- Journal / source
- Organic Letters
- Publisher
- American Chemical Society (ACS)
- Volume
- 28
- Issue
- 19
- Pages
- 6054–6059
- Publication date
- 4 May 2026
- Language
- EN