Regioselective Reductive Coupling of o -Haloaromatic Ketones with Terminal Alkynes via Photoredox/Cobalt Dual Catalysis

Organic Letters 2026

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Authors: Qian Gui-fen, Ruo-ping Zheng, Tingting Miao, Yonghong Xiao, Sanliang Li, Jian-Ji Zhong
DOI: 10.1021/acs.orglett.6c01347
Cited by: 5
References: 66

Abstract

-bromoaromatic aldehydes, with terminal alkynes to afford 2-substituted indenols. This protocol uses a tertiary amine as the terminal reductant, proceeds at room temperature, and features mild conditions, excellent regioselectivity, and broad substrate scope.

Fields of Study & Subjects

Catalytic C–H Functionalization Methods Radical Photochemical Reactions Catalytic Cross-Coupling Reactions

Publication details

Journal / source
Organic Letters
Publisher
American Chemical Society (ACS)
Volume
28
Issue
19
Pages
6089–6095
Publication date
29 April 2026
Language
EN