One-Pot Synthesis of Nitriles from Aldehydes Enabled by Amino-λ 3 -iodane

Organic Letters 2026

View at publisher
Authors: Dan Xiao, Jiaxin He, Kaiyue Yang, Zhijian Wang, Liujing Feng, Wei Zhang, Yunfei Du
DOI: 10.1021/acs.orglett.6c01387
Cited by: 1
References: 67

Abstract

, as an efficient cyanating agent, undergoes nucleophilic addition with aldehydes to form imines, followed by elimination of the resulting imines, which is facilitated by the excellent leaving-group ability of the iodine(III) center to afford nitrile products. This protocol proceeds smoothly with a broad scope of aldehydes, delivering the corresponding nitriles in good to excellent yields under base-free conditions.

Fields of Study & Subjects

Oxidative Organic Chemistry Reactions Catalytic C–H Functionalization Methods Vanadium and Halogenation Chemistry

Publication details

Journal / source
Organic Letters
Publisher
American Chemical Society (ACS)
Volume
28
Issue
17
Pages
5644–5650
Publication date
17 April 2026
Language
EN