Phosphine-Catalyzed [3+3] Annulation of Electron-Deficient Enyne-Type Propargylic Carbonates with α-Cyano Ketones

Organic Letters 2026

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Authors: Jingrong Jin, Haoran Wang, Bo Wang, Yi Tang, Honghao Sun, Zhiyang Cui, L J Zhou, Hongchao Guo
DOI: 10.1021/acs.orglett.6c01404
Cited by: 1
References: 45

Abstract

A novel phosphine-catalyzed [3+3] annulation of electron-deficient enyne-type propargylic carbonates with α-cyano ketones has been developed, giving tetrasubstituted γ-pyran derivatives in high yields. In this reaction, 1,2,3-butatriene phosphonium intermediates formed in situ acted as dielectrophilic reagents. This represents the first example of electron-deficient enyne-type propargylic carbonates being used as phosphine acceptors in phosphine catalysis.

Fields of Study & Subjects

Catalytic Alkyne Reactions Catalytic Cross-Coupling Reactions Carbon dioxide utilization in catalysis

Publication details

Journal / source
Organic Letters
Publisher
American Chemical Society (ACS)
Volume
28
Issue
20
Pages
6312–6317
Publication date
8 May 2026
Language
EN