Electrophilic Activation of CO 2 -Derived Bis(silyl)acetal for Asymmetric Bridging Reactions

Organic Letters 2026

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Authors: Zhiyu Cao, Wenhao Xu, Xiaoping Wang, Xu Xu, Jingyu Zhang, Yingsheng Zhao
DOI: 10.1021/acs.orglett.6c01411
Cited by: 1
References: 36

Abstract

The current study reports a strategy for the electrophilic activation of CO 2 -derived bis(silyl)acetal. Under mild reaction conditions, it was utilized as a C1 synthon for the synthesis of symmetric and asymmetric diarylmethanes via catalysis by N -heterocyclic carbenes (NHCs) with silane as a reductant, converting bis(silyl)acetals, a traditional reaction acceptor, into an electrophile under acidic conditions. The proposed strategy drives a Friedel–Crafts electrophilic substitution reaction, enabling the efficient synthesis of asymmetric diarylmethane products.

Fields of Study & Subjects

Carbon dioxide utilization in catalysis N-Heterocyclic Carbenes in Organic and Inorganic Chemistry Cyclopropane Reaction Mechanisms

Publication details

Journal / source
Organic Letters
Publisher
American Chemical Society (ACS)
Volume
28
Issue
21
Pages
6619–6624
Publication date
15 May 2026
Language
EN