Mechanochemical Rh(I)-Catalyzed C–N/C–C/C–H Triple Bond Activation of Amides

Organic Letters 2026

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Authors: Jin Zhang, Renjie Li, Yawei Zhu, Linqin Shang, Siqi Jiang, Nana Chen, Jianbo Tong, Michal Szostak
DOI: 10.1021/acs.orglett.6c01505
Cited by: 1
References: 36

Abstract

Direct decarbonylative triple C-N, C-C, and C-H functionalization of amides with hydrocarbons has been accomplished under mechanochemical conditions via Rh(I) catalysis. This method exhibits excellent substrate versatility in high-yielding couplings with diverse aromatic compounds, and its utility is highlighted by late-stage pharmaceutical derivatization and orthogonal C-X and C-N sequential cross-couplings. This solvent-free mechanochemical approach drastically lowers the temperature required for triple amide activation, overcoming kinetic barriers through a sustainable pathway.

Fields of Study & Subjects

Catalytic C–H Functionalization Methods Catalytic Cross-Coupling Reactions Organoboron and organosilicon chemistry

Publication details

Journal / source
Organic Letters
Publisher
American Chemical Society (ACS)
Volume
28
Issue
17
Pages
5651–5656
Publication date
22 April 2026
Language
EN