Dfpenicimeroterpenoid A, Meroterpenoids with 6/6/6/4/5 Polycyclic Skeletons from the Marine-Derived Fungus Penicillium sp. DF71
Abstract
A novel andrastin-type meroterpenoid, dfpenicimeroterpenoid A ( 1 ), featuring an unprecedented fused 6/6/6/4/5 pentacyclic skeleton is described, along with four new analogues from marine-derived fungus Penicillium sp. DF71. The structures were established by analysis of their spectroscopic data, single-crystal X-ray diffraction, and quantum chemical calculations of electronic circular dichroism spectra. Compound 2 showed significant pro-angiogenic activity at a concentration of 20 μM, based on a zebrafish model. Furthermore, a plausible biosynthetic pathway for 1 is proposed.
Fields of Study & Subjects
Microbial Natural Products and Biosynthesis
Marine Sponges and Natural Products
Seaweed-derived Bioactive Compounds
Publication details
- Journal / source
- Organic Letters
- Publisher
- American Chemical Society (ACS)
- Volume
- 28
- Issue
- 27
- Pages
- 8549–8553
- Publication date
- 26 June 2026
- Language
- EN