Stereospecific N-Glycosylation Strategy for β- N -Glycoside Synthesis via Base Catalysis
Abstract
-glycosides bearing heteroaryl, aryl, alkyl, and nucleobase functionalities. This approach features high yields and outstanding β-stereocontrol and obviates the need for traditional stereodirecting groups. Notably, late-stage modification of structurally complex drug molecules demonstrates the synthetic potential of this powerful approach.
Fields of Study & Subjects
Carbohydrate Chemistry and Synthesis
HIV/AIDS drug development and treatment
Asymmetric Synthesis and Catalysis
Publication details
- Journal / source
- Organic Letters
- Publisher
- American Chemical Society (ACS)
- Volume
- 28
- Issue
- 18
- Pages
- 5882–5888
- Publication date
- 28 April 2026
- Language
- EN