A Light-Activated Nickel Catalyst for the Carbonylation of Alkyl Halides
Abstract
We describe a versatile method for using earth-abundant nickel catalysts in carbonylative coupling reactions. In this process, the wavelength-dependent excitation of a Xantphos-ligated nickel in concert with a weakly nucleophilic fluoride anion offers a route to build up acyl fluorides in high yield from classically unreactive C(sp 3 ) bromides. Coupling the formation of the acyl fluorides with subsequent nucleophilic addition can be used to construct a diverse array of amides, esters, and thioesters via carbonylations.
Fields of Study & Subjects
Catalytic Cross-Coupling Reactions
Catalytic C–H Functionalization Methods
Radical Photochemical Reactions
Publication details
- Journal / source
- Organic Letters
- Publisher
- American Chemical Society (ACS)
- Volume
- 28
- Issue
- 22
- Pages
- 6926–6931
- Publication date
- 26 May 2026
- Language
- EN