Assembly of Chiral Helical Quinones via Enantioselective Organocatalytic [4+2] Annulation
Abstract
Chiral helicenes are widely found in materials science, self-assembly, and asymmetric catalysis, yet their asymmetric construction remains highly challenging. Herein, we report an unprecedented asymmetric synthesis of helical quinones via an enantioselective amine-catalyzed [4+2] annulation. This method features a broad substrate scope, excellent functional group tolerance, and moderate to good yields with high enantioselectivities, providing a new strategy for the construction of chiral helicenes.
Fields of Study & Subjects
Synthesis and Properties of Aromatic Compounds
Axial and Atropisomeric Chirality Synthesis
Supramolecular Chemistry and Complexes
Publication details
- Journal / source
- Organic Letters
- Publisher
- American Chemical Society (ACS)
- Volume
- 28
- Issue
- 21
- Pages
- 6728–6734
- Publication date
- 14 May 2026
- Language
- EN