Palladium-Catalyzed Enantioselective Decarboxylative Hydrobenzylation of Allenes with Aryl Acetic Acids

Organic Letters 2026

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Authors: Jian-Bin Lu, Q F Liu, Qian-Qian Yang, Wei Du, Ying‐Chun Chen
DOI: 10.1021/acs.orglett.6c01604
Cited by: 1
References: 33

Abstract

We report a palladium-catalyzed asymmetric hydrobenzylation reaction of alkoxy- and amidoallenes with aryl acetic acids by in situ forming labile acetal-type intermediates, and a diverse array of enantioenriched allylic ethers and amides bearing a homobenzylic stereogenic center are finally afforded after decarboxylation.

Fields of Study & Subjects

Catalytic C–H Functionalization Methods Catalytic Alkyne Reactions Asymmetric Hydrogenation and Catalysis

Publication details

Journal / source
Organic Letters
Publisher
American Chemical Society (ACS)
Volume
28
Issue
23
Pages
7164–7168
Publication date
1 June 2026
Language
EN