Light-Enabled C–F Bond Functionalization of α-Trifluoromethyl Alkenes toward gem -Difluoroallyl Organogermanium Herbicides

Organic Letters 2026

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Authors: Yue Zhang, Song Kou, Zichuan Ren, Yingnan Xie, Zexiu An, Lai Chen, Jingqian Huo, Jinlin Zhang
DOI: 10.1021/acs.orglett.6c01613
Cited by: 1
References: 44

Abstract

This study describes a visible-light-driven photoredox/HAT cocatalytic strategy for the efficient synthesis of functionalized 3,3-difluoroallyl organogermanium compounds. Bioactivity studies indicate that representative compound 3q exhibits significant herbicidal activity against Portulaca oleracea L. with an inhibition rate of 72.6%, comparable to the commercial herbicide atrazine. Integrating continuous-flow technology enabled gram-scale synthesis. This work provides an approach to fluorinated organogermanium compounds and may facilitate the development of agrochemical agents.

Fields of Study & Subjects

Fluorine in Organic Chemistry Chemical Reactions and Isotopes Radical Photochemical Reactions

Publication details

Journal / source
Organic Letters
Publisher
American Chemical Society (ACS)
Volume
28
Issue
21
Pages
6751–6755
Publication date
19 May 2026
Language
EN