Rhodium-Catalyzed [2 + 1] Annulation of Alkynyl Acylsilanes with Diazoacetates: Access to Tetrasubstituted Epoxides

Organic Letters 2026

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Authors: Guang-Hui Li, Xue-Di Zhao, Shengchao Yang, Lijia Wang, Lu Liu
DOI: 10.1021/acs.orglett.6c01615
Cited by: 1
References: 66

Abstract

-catalyzed [2 + 1] annulation of alkynyl acylsilanes with aryl diazoacetates has been developed, affording a wide range of functionalized tetrasubstituted epoxides in high yields. This method features broad substrate scope, excellent functional group compatibility, and gram-scale scalability. The synthetic utility of the resulting epoxides is also demonstrated by diverse chemical transformations.

Fields of Study & Subjects

Cyclopropane Reaction Mechanisms Catalytic C–H Functionalization Methods Catalytic Cross-Coupling Reactions

Publication details

Journal / source
Organic Letters
Publisher
American Chemical Society (ACS)
Volume
28
Issue
23
Pages
7185–7190
Publication date
3 June 2026
Language
EN