Mechanochemical Aminocarbonylation of Unactivated Arenes Leveraging in Situ Thianthrenation and Using FeBr 2 (CO) 4 as a CO Surrogate
Abstract
Here, we present a convergent synthesis of aromatic carboxamides from unactivated arenes using FeBr 2 (CO) 4 as a CO source and the corresponding amine. The reaction involves the in situ formation of arene thianthrenium salts, which participate in the Pd-catalyzed carbonylation step, affording a broad range of carboxamides, including late-stage derivatization of several complex, medicinally and biologically relevant compounds. Mechanistic studies suggest that CO coordination precedes oxidative oxidation, thereby resulting in a highly selective carbonylative process.
Fields of Study & Subjects
Catalytic Cross-Coupling Reactions
Catalytic C–H Functionalization Methods
Carbon dioxide utilization in catalysis
Publication details
- Journal / source
- Organic Letters
- Publisher
- American Chemical Society (ACS)
- Volume
- 28
- Issue
- 23
- Pages
- 7260–7265
- Publication date
- 4 June 2026
- Language
- EN