Photocatalytic Deacylative 1,2-Alkyl(hetero)arylation of Electron-Rich Styrenes

Organic Letters 2026

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Authors: Subham Das, Snehajit Chakraborty, Christy Anna Varghese, Basudev Sahoo
DOI: 10.1021/acs.orglett.6c01740
Cited by: 1
References: 43

Abstract

We report a mild photoredox-catalyzed deacylative three-component 1,2-alkyl(hetero)arylation of electron-rich styrenes with unstrained ketone-derived dihydroquinazolinones and electron-rich (hetero)arenes, showcasing high substrate compatibility under oxidative conditions. The radical–polar crossover blueprint uniquely integrates deacylative radical C(sp 3 )–C(sp 3 ) bond formation with polar electrophilic aromatic substitution (S E Ar)-driven C(sp 3 )–C(sp 2 ) bond construction, overcoming competitive N-alkylation and E1-elimination. This method mostly offers a direct route to 1-aryl-1′-heteroarylalkanes and unsymmetrical 1,1-bis(heteroaryl)alkanes.

Fields of Study & Subjects

Radical Photochemical Reactions Catalytic Cross-Coupling Reactions Organic and Inorganic Chemical Reactions

Publication details

Journal / source
Organic Letters
Publisher
American Chemical Society (ACS)
Volume
28
Issue
22
Pages
7038–7043
Publication date
26 May 2026
Language
EN