Palladium-Catalyzed Markovnikov Hydrocarbonylation of Aliphatic Olefins: A General Approach to Diverse Carbonyl Compounds

Organic Letters 2026

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Authors: Fei Wu, Kuo-huai Qin, Yu-Yan Lian, Zhi‐Hui Ren, Zheng‐Hui Guan
DOI: 10.1021/acs.orglett.6c01754
Cited by: 1
References: 43

Abstract

A unified palladium-catalyzed Markovnikov hydrocarbonylation of aliphatic olefins has been reported. The use of a biaryl scaffold monophosphine ligand is crucial to achieving excellent branched regioselectivity. This versatile catalytic system exhibits excellent compatibility with a series of nucleophiles, including anilines, water, and alcohols, enabling efficient and regioselective construction of structurally diverse branched carbonyl compounds from readily accessible aliphatic olefins. The synthetic utility of this method was demonstrated by the efficient preparation of agrochemicals and fine chemicals.

Fields of Study & Subjects

Catalytic C–H Functionalization Methods Catalytic Cross-Coupling Reactions Sulfur-Based Synthesis Techniques

Publication details

Journal / source
Organic Letters
Publisher
American Chemical Society (ACS)
Volume
28
Issue
26
Pages
8289–8293
Publication date
17 June 2026
Language
EN