Chaeglobocinnin A and Chaeglobokojin A: Chaetoviridin Azaphilone–Cinnamic Acid and −Kojic Acid Hybrids with Anti-Liver Fibrosis Activity from an Endophytic Chaetomium globosum
Abstract
Two unprecedented azaphilone hybrids─chaeglobocinnin A ( 1 ) and chaeglobokojin A ( 2 )─featuring chaetoviridin-type cores coupled with cinnamic acid and kojic acid, respectively, were isolated from an endophytic fungus Chaetomium globosum . 1 features a 6/6/6/6 fused tetracyclic framework with a benzene ring attached as a pendant moiety. 2 possesses an unprecedented 6/6/5/6/6 pentacyclic system characterized by a spiro moiety. Their structures were unequivocally established by comprehensive spectroscopic analysis, NMR calculations with DP4+ probability analysis, and single-crystal X-ray diffraction. Additionally, 2 exhibited antiliver fibrosis activity via inhibition of the TGF-β/Smad signaling pathway.
Fields of Study & Subjects
Traditional and Medicinal Uses of Annonaceae
Chromatography in Natural Products
Plant Toxicity and Pharmacological Properties
Publication details
- Journal / source
- Organic Letters
- Publisher
- American Chemical Society (ACS)
- Volume
- 28
- Issue
- 23
- Pages
- 7304–7309
- Publication date
- 3 June 2026
- Language
- EN