Harnessing Sulfilimines for Nitrene O–H Insertion: A Direct Route to Hydroxamic Acid Esters

Organic Letters 2026

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Authors: Xia Liu, Zhe Jin, Chongjie Su, J Jay Liu, Xinyu Lu, Yuqiang Liu, Chaole Han, Penghao Jia
DOI: 10.1021/acs.orglett.6c01793
Cited by: 1
References: 58

Abstract

Direct O-H insertion into alcohols has long remained a challenge in nitrene chemistry. We now report the first general photocatalytic strategy to address this gap, using sulfilimines as nitrene precursors to deliver the privileged hydroxamic acid ester pharmacophore from abundant alcohols under mild, additive-free conditions. The method features broad scope and excellent chemoselectivity and extends to the first nitrene insertion into aliphatic primary amines for N-N coupling.

Fields of Study & Subjects

Synthesis and Catalytic Reactions Chemical Reactions and Mechanisms Radical Photochemical Reactions

Publication details

Journal / source
Organic Letters
Publisher
American Chemical Society (ACS)
Volume
28
Issue
23
Pages
7343–7348
Publication date
4 June 2026
Language
EN