Nickel-Catalyzed Enantioselective Hydroboration of Enamides
Abstract
Enantioselective hydroboration of alkenes has become a powerful strategy for the synthesis of enantioenriched alkylboron compounds. However, analogous reactions involving electron-rich internal alkenes, such as enamides, remain largely underdeveloped and mainly limited to precious rhodium catalysis. Herein, we reported the first nickel-catalyzed enantioselective hydroboration of unactivated enamides, affording medicinally valuable β-amino boronates with high regio- and enantioselectivity (>20:1 r.r. and up to 96% ee). This earth-abundant metal system employs commercially available metal catalysts and ligands and operates under mild conditions, providing a practical and efficient platform for synthetic and medicinal chemistry.
Fields of Study & Subjects
Organoboron and organosilicon chemistry
Catalytic C–H Functionalization Methods
Asymmetric Hydrogenation and Catalysis
Publication details
- Journal / source
- Organic Letters
- Publisher
- American Chemical Society (ACS)
- Volume
- 28
- Issue
- 23
- Pages
- 7362–7368
- Publication date
- 1 June 2026
- Language
- EN