Enantioselective Assembly of Planar-Chiral and Axial-Planar-Chiral Macrocycles via De Novo Isoquinolinone Formation

Organic Letters 2026

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Authors: Wenkai Li, Ke Yang, Xiaoli Gu, Shanshan Shi, Yuhan Zhou, Jingping Qü, Baomin Wang
DOI: 10.1021/acs.orglett.6c01822
Cited by: 1
References: 84

Abstract

A mild cobalt/salicyloxazoline (Salox)-catalyzed intramolecular C-H macrocyclization is reported. This method enables the enantioselective synthesis of planar-chiral macrocycles as well as scaffolds integrating planar and axial chirality. The reaction proceeds under mild conditions, shows broad substrate scope, and delivers products in yields of 42% to 73% with excellent enantioselectivities (up to 99% ee). This work establishes a versatile platform for constructing constrained, three-dimensional macrocyclic architectures.

Fields of Study & Subjects

Synthesis and Properties of Aromatic Compounds Supramolecular Self-Assembly in Materials Supramolecular Chemistry and Complexes

Publication details

Journal / source
Organic Letters
Publisher
American Chemical Society (ACS)
Volume
28
Issue
25
Pages
7994–7999
Publication date
15 June 2026
Language
EN