Dicarbofunctionalization of [1.1.1]Propellane: One-Step Multicomponent Approach to BCP-Aryl Derivatives

Organic Letters 2026

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Authors: Yumei Huo, Liangyu Liu
DOI: 10.1021/acs.orglett.6c01849
Cited by: 1
References: 52

Abstract

Aryl-substituted bicyclo[1.1.1]pentanes (BCPs) are valuable scaffolds in drug discovery. However, their synthesis typically requires multistep sequences via prefunctionalized [1.1.1]pentane. Herein, we report a metal-free, visible-light-driven three-component dicarbofunctionalization of [1.1.1]propellane via an electron donor-acceptor (EDA) complex. This method provides direct and diverse access to 1,3-disubstituted BCPs under mild conditions with operational simplicity and green chemistry, featuring good functional group tolerance from readily available starting materials.

Fields of Study & Subjects

Radical Photochemical Reactions Synthesis and Properties of Aromatic Compounds Photochromic and Fluorescence Chemistry

Publication details

Journal / source
Organic Letters
Publisher
American Chemical Society (ACS)
Volume
28
Issue
24
Pages
7692–7697
Publication date
8 June 2026
Language
EN