Pd-Catalyzed Vinylic C–H Funtionalization for the Synthesis of 1,4-Disilylated 1,3-Dienes
Abstract
A palladium-catalyzed C–H silylation reaction of alkenyl triflates has been developed, employing a norbornene analogue as a relay for C–H activation. The reaction forms C(vinyl), C(alkyl)-palladacycles as the key intermediates via norbornene analogue-relayed C–H activation. These palladacycles subsequently react with a disilane to form disilylated intermediates, which undergo a retro-Diels–Alder reaction to deliver the final products. This method offers an efficient route to Z, Z -1,4-disilylated 1,3-dienes.
Fields of Study & Subjects
Catalytic C–H Functionalization Methods
Catalytic Cross-Coupling Reactions
Organoboron and organosilicon chemistry
Publication details
- Journal / source
- Organic Letters
- Publisher
- American Chemical Society (ACS)
- Volume
- 28
- Issue
- 23
- Pages
- 7409–7414
- Publication date
- 3 June 2026
- Language
- EN