Organocatalytic Nucleophilic Aromatic Addition Enabling Asymmetric Dearomatization of Azoindoles with Indoles

Organic Letters 2026

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Authors: Shen-Xu Xu, Wei Wang, Y Zhang, Jing Zhang, Ke Chen, Wen‐Juan Hao, Bo Jiang
DOI: 10.1021/acs.orglett.6c01896
Cited by: 1
References: 67

Abstract

Catalytic asymmetric dearomatization represents a powerful means to convert flat aromatic compounds into stereochemically well-defined three-dimensional molecular architectures. Herein, we report a chiral phosphoric acid-catalyzed nucleophilic aromatic addition of azoindoles with indoles, enabling asymmetric dearomatization to deliver a broad array of C2-tertiary stereogenic indolines in good to excellent yields with uniform enantioselectivity and complete Z -selectivity.

Fields of Study & Subjects

Asymmetric Synthesis and Catalysis Catalytic C–H Functionalization Methods Axial and Atropisomeric Chirality Synthesis

Publication details

Journal / source
Organic Letters
Publisher
American Chemical Society (ACS)
Volume
28
Issue
25
Pages
8018–8024
Publication date
10 June 2026
Language
EN