Reductive Cross-Coupling of Alkynes with Aryl Bromides via Zr/Pd Synergistic Catalysis

Organic Letters 2026 Open access

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Authors: Marymoud Erzuah, Abhishek Raj, Rebecca A. Kehner, Liela Bayeh-Romero
DOI: 10.1021/acs.orglett.6c01949
Cited by: 1
References: 40

Abstract

High Resolution Image Download MS PowerPoint Slide The cocatalytic reductive cross-coupling of unactivated alkynes with aryl bromides is reported, using 2 mol % Pd(PPh 3 ) 4 and 10 mol % Cp 2 ZrCl 2 in combination with a hydrosilane reductant. Hydroarylated products are furnished in upward of 91% yield across 25 elaborated substrates, including those containing unprotected alcohols, esters, amides, and terminal alkenes. Syn -selective hydrozirconation of alkyne substrates prior to transmetalation ensures exceptional (>20:1) (E) -selectivity across all alkene products. Further, this protocol was successfully implemented on gram scale without loss of efficiency or selectivity.

Fields of Study & Subjects

Catalytic Cross-Coupling Reactions Catalytic C–H Functionalization Methods Environmental remediation with nanomaterials

Publication details

Journal / source
Organic Letters
Publisher
American Chemical Society (ACS)
Volume
28
Issue
23
Pages
7455–7459
Publication date
28 May 2026
Language
EN