Base-Mediated Self-Organization of Acetylene Gas, Nitriles, and Ketones

Organic Letters 2026

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Authors: Elena Yu. Schmidt, Nadezhda V. Semenova, Evgeniya A. Golub’, Igor A. Ushakov, Alexander S. Bobkov, Yuliya A. Orlyuk, Boris A. Trofimov
DOI: 10.1021/acs.orglett.6c01962
Cited by: 1
References: 30

Abstract

An efficient approach to access diversely substituted pyridines via a three-component reaction of industrially available acetylene gas, nitriles, and ketones under basic conditions has been developed. This multimolecular self-organization is triggered by the addition of acetylenic carbanions to the C≡N bond of nitrile followed by the involvement of the ketone molecule to build up the pyridine ring. The broad range of simple substrates, one-pot operation, transition-metal-free conditions, and wide variety of synthesized pyridine-tailored heterocyclic systems make the approach of high practical value alone theoretically significant.

Fields of Study & Subjects

Synthesis and Characterization of Pyrroles Origins and Evolution of Life Molecular Spectroscopy and Structure

Publication details

Journal / source
Organic Letters
Publisher
American Chemical Society (ACS)
Volume
28
Issue
25
Pages
8060–8065
Publication date
3 June 2026
Language
EN