Non-decarboxylative C–H Fluorination of Carboxylic Acids by Iridium Photocatalysis
Abstract
High Resolution Image Download MS PowerPoint Slide We have developed a photoredox-initiated non-decarboxylative C–H fluorination of carboxylic acids. Using Selectfluor as the fluorinating agent, a range of primary and secondary carboxylic acids were site-selectively fluorinated at their β- to ϵ-positions. Mechanistic studies suggest that the reaction proceeds by photocatalytic reduction of Selectfluor, generating an N -centered radical that mediates intermolecular hydrogen atom abstraction and propagates a radical chain fluorination process.
Fields of Study & Subjects
Fluorine in Organic Chemistry
Radical Photochemical Reactions
Catalytic C–H Functionalization Methods
Publication details
- Journal / source
- Organic Letters
- Publisher
- American Chemical Society (ACS)
- Volume
- 28
- Issue
- 24
- Pages
- 7772–7777
- Publication date
- 10 June 2026
- Language
- EN