Light-Driven Iron-Mediated Thiotrifluoromethylation of Alkenes Using CF 3 CO 2 H
Abstract
-aryl benzenesulfonothioates as arylthio donors. Under purple-light irradiation, simple iron(III) salts enable a three-component reaction that affords diverse aryl 3,3,3-trifluoropropyl sulfides with broad scope and good functional group tolerance. The products are readily elaborated and applied to late-stage modification of complex molecules, providing a simple and scalable route to fluorinated sulfur-containing scaffolds.
Fields of Study & Subjects
Fluorine in Organic Chemistry
Sulfur-Based Synthesis Techniques
Radical Photochemical Reactions
Publication details
- Journal / source
- Organic Letters
- Publisher
- American Chemical Society (ACS)
- Volume
- 28
- Issue
- 24
- Pages
- 7857–7862
- Publication date
- 9 June 2026
- Language
- EN