Molybdenum-Catalyzed Intramolecular Deoxygenative Annulation of 2-(Formamido)aryl Ketones to Access 3-Monosubstituted Oxindoles

Organic Letters 2026

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Authors: Haoke Chu, Xiuxin Lv, Li Luo, Jiya Yuan, Fengqian Chen
DOI: 10.1021/acs.orglett.6c02113
Cited by: 1
References: 61

Abstract

A molybdenum-catalyzed deoxygenative annulation of 2-(formamido)aryl ketones to access 3-monosubstituted oxindole compounds with broad functional group tolerance is described. The valuable product can be converted into various derivatives, and the catalytic conditions can be applied in drug modification and synthesis of the known bioactive compound. Mechanisms involving Mo–carbene insertion into the C(sp 2 )–H bond or 1,2-hydride shift are proposed.

Fields of Study & Subjects

Catalytic C–H Functionalization Methods Catalytic Cross-Coupling Reactions Catalytic Alkyne Reactions

Publication details

Journal / source
Organic Letters
Publisher
American Chemical Society (ACS)
Volume
28
Issue
28
Pages
8818–8823
Publication date
7 July 2026
Language
EN