Palladium-Catalyzed Ring-Opening Defluoroarylation of gem -Difluorinated Spiro[2.2]pentanes with Arylboronic Acids

Organic Letters 2026

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Authors: Wen-Mei Luo, Huang Zhuo-yao, Bao-Yi Liu, Chen Li, Jin‐Bao Peng, Zhiyuan Tan
DOI: 10.1021/acs.orglett.6c02114
Cited by: 1
References: 59

Abstract

A palladium-catalyzed ring-opening defluoroarylation of gem -difluorinated spiro[2.2]pentanes with arylboronic acids has been developed. A diverse range of multisubstituted 2-fluoro-1,3-dienes was efficiently prepared in moderate to excellent yields. The resulting conjugated diene products serve as versatile synthetic precursors, facilitating downstream derivatization through Diels–Alder reactions, cross-coupling reactions, and oxidation/reduction transformations. A variety of highly useful structural motifs were constructed, thereby expanding the utility of gem -difluorinated spiro[2.2]pentanes as versatile building blocks in organic synthesis.

Fields of Study & Subjects

Fluorine in Organic Chemistry Catalytic C–H Functionalization Methods Catalytic Cross-Coupling Reactions

Publication details

Journal / source
Organic Letters
Publisher
American Chemical Society (ACS)
Volume
28
Issue
27
Pages
8621–8626
Publication date
29 June 2026
Language
EN