Cobalt/Photoredox Dual-Catalyzed Alkylation of Indole with Unactivated Alkenes

Organic Letters 2026

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Authors: Honglin Dong, Xingru Yan, Mengzhe Liang, Meitong Qu, Ge Zhang, Qian Zhang
DOI: 10.1021/acs.orglett.6c02216
Cited by: 1
References: 54

Abstract

We herein report an efficient and scalable alkylation of indole with unactivated alkenes via a dual photoredox- and cobalt-catalyzed metal hydride hydrogen atom transfer (MHAT) and radical-polar crossover process. The reaction features a broad substrate scope and good functional group tolerance, providing access to structurally diverse C3-alkylated indole derivatives in good to excellent yields. This work offers a new strategy for the highly selective alkylation of indoles without restrictions on any reaction components and represents an important complement to existing MHAT-mediated alkene hydrofunctionalization with nucleophiles.

Fields of Study & Subjects

Catalytic C–H Functionalization Methods Radical Photochemical Reactions Asymmetric Hydrogenation and Catalysis

Publication details

Journal / source
Organic Letters
Publisher
American Chemical Society (ACS)
Volume
28
Issue
28
Pages
8847–8852
Publication date
1 July 2026
Language
EN