Sandwich-SuFEx Cyclization Enables One-Pot Synthesis of Multicyclic Peptides with Tunable Topologies

Organic Letters 2026

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Authors: Tianxiong Mi, Lijun Fan, Erwin G. Abucayon, Diego B. Diaz, Jack D. Scott
DOI: 10.1021/acs.orglett.6c02220
Cited by: 1
References: 35

Abstract

Sandwich-SuFEx (sulfur(VI) fluoride exchange) cyclization is introduced as a rapid, aqueous cross-linking reaction complementary to CuAAC and thioether formation. Di- or triarmed aryl sulfonyl fluorides selectively capture peptide phenols to afford terphenyl-bridged macrocycles spanning 5- to 12-mers, tolerating diverse side chains and linker designs. One-pot reactions combining sandwich-SuFEx with thioether formation assemble bi-, tri-, and tetracyclic peptides with tunable topologies in

Fields of Study & Subjects

Chemical Synthesis and Analysis Fluorine in Organic Chemistry Click Chemistry and Applications

Publication details

Journal / source
Organic Letters
Publisher
American Chemical Society (ACS)
Volume
28
Issue
31
Pages
9853–9859
Publication date
23 July 2026
Language
EN