Photocatalytic C-3 Acylation of Indoles Using ICF 2 SO 2 Ph as Acyl Fluoride Precursor

Organic Letters 2026

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Authors: Jiarui Liang, Dandan Xia, Huanyi Guo, Xin Guo, Guoliang Pu, Yang Huang, Qiuli Yao, Chun‐Yang He
DOI: 10.1021/acs.orglett.6c02224
Cited by: 1
References: 37

Abstract

ICF 2 SO 2 Ph represents an important reagent for introducing the CF 2 SO 2 Ph functionality into organic scaffolds. Here, we found that ICF 2 SO 2 Ph acts as an acyl fluoride precursor, enabling the C-3 acylation of indoles. Under mild visible light photocatalysis, this reaction proceeds smoothly with various nucleophiles. Mechanistic studies confirm that acyl fluoride is generated via cleavage and recombination of ICF 2 SO 2 Ph. This work expands the synthetic utility of this reagent and provides a novel photocatalytic strategy for the direct C-3 acylation of indoles.

Fields of Study & Subjects

Fluorine in Organic Chemistry Radical Photochemical Reactions Sulfur-Based Synthesis Techniques

Publication details

Journal / source
Organic Letters
Publisher
American Chemical Society (ACS)
Volume
28
Issue
26
Pages
8463–8468
Publication date
22 June 2026
Language
EN