Visible-Light-Promoted Carbamoylation: Access to Diarylhydrazine Carbonyl Amino Acid/Peptide Derivatives

Organic Letters 2026

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Authors: Fan‐Lin Zeng, L Wang, Yuxin Luo, Jinwei Yuan, Bing Yu, Teck‐Peng Loh
DOI: 10.1021/acs.orglett.6c02274
Cited by: 1
References: 64

Abstract

Integrating amino acids/peptides into hydrazine skeletons remains a significant challenge. We report a visible-light-induced carbamoylation using DHP-tagged amino acids/peptides as radical precursors for the green synthesis of diarylhydrazine carbonyl amino acid/peptide derivatives (37 examples, up to 96% yield). This first integration of amino acid/peptide motifs into hydrazines features mild conditions, external oxidant/additive-free, broad substrate scope and excellent compatibility. It enables late-stage modification of proteins/amine-containing functional molecules, offering a sustainable strategy for peptide modification and drug discovery.

Fields of Study & Subjects

Radical Photochemical Reactions Sulfur-Based Synthesis Techniques Synthesis and Catalytic Reactions

Publication details

Journal / source
Organic Letters
Publisher
American Chemical Society (ACS)
Volume
28
Issue
27
Pages
8672–8677
Publication date
30 June 2026
Language
EN