Modular Access to Alkyl Germanes Via Ni-Catalyzed Regioselective Reductive Arylgermylation of Activated Alkenes
Abstract
Herein, we report a modular and practical nickel-catalyzed reductive arylgermylation of activated alkenes by employing readily available aryl/vinyl (pseudo)halides and commercial chlorogermanes. A broad range of activated alkenes with diverse functional groups are well-compatible under mild reaction conditions, delivering a series of valuable alkylgermanes in high efficiency. Notably, synthetically useful 1,1-borylgermyl compounds, which have been validated as versatile building blocks, can be efficiently assembled via this protocol, further demonstrating the synthetic utility of this method.
Fields of Study & Subjects
Catalytic C–H Functionalization Methods
Catalytic Cross-Coupling Reactions
Organoboron and organosilicon chemistry
Publication details
- Journal / source
- Organic Letters
- Publisher
- American Chemical Society (ACS)
- Volume
- 28
- Issue
- 26
- Pages
- 8528–8534
- Publication date
- 17 June 2026
- Language
- EN