Electrochemical Dehydroxylative Thiolation of Alkyl Alcohols with Disulfides

Organic Letters 2026

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Authors: Jianshu Yue, Yukang He, Yinghui Shao, J Chen, Hong‐Ping Deng, Mengtao Ma, Fei Xue
DOI: 10.1021/acs.orglett.6c02411
Cited by: 1
References: 65

Abstract

Herein, we report a metal-free electrochemical protocol for the direct thiolation of alkyl alcohols with odorless disulfides under mild conditions. This strategy features a broad substrate scope, excellent functional-group tolerance, and applicability to the late-stage functionalization of complex bioactive molecules, providing an efficient and sustainable platform for C-S bond formation. Furthermore, a series of control experiments highly suggest a plausible iodide/phosphine-mediated radical pathway for this transformation.

Fields of Study & Subjects

Radical Photochemical Reactions Sulfur-Based Synthesis Techniques Oxidative Organic Chemistry Reactions

Publication details

Journal / source
Organic Letters
Publisher
American Chemical Society (ACS)
Volume
28
Issue
28
Pages
8958–8963
Publication date
8 July 2026
Language
EN