The Exploration of TPhos as a Monodentate P-Ligand for Palladium-Catalyzed Regioselective Hydrothiocarbonylation of Styrenes under Neutral Conditions

Organic Letters 2026 Open access

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Authors: Chang‐Sheng Kuai, Wen Che, Shou‐Fei Zhu, Xiao‐Feng Wu
DOI: 10.1021/acs.orglett.6c02424
Cited by: 1
References: 49

Abstract

A palladium-catalyzed nonacidic hydrothiocarbonylation of styrenes with CO and thiols has been developed. Utilizing a cyclopropane-based monophosphine ligand (TPhos), this protocol enables the efficient and branched-selective synthesis of alkyl thioesters under mild and neutral conditions with broad substrate scope and excellent functional group tolerance.

Fields of Study & Subjects

Catalytic C–H Functionalization Methods Catalytic Cross-Coupling Reactions Asymmetric Hydrogenation and Catalysis

Publication details

Journal / source
Organic Letters
Publisher
American Chemical Society (ACS)
Volume
28
Issue
27
Pages
8718–8723
Publication date
29 June 2026
Language
EN