Chiral Hydroxamic Ester-Enabled Asymmetric Catellani Reaction for the Synthesis of P -Stereogenic Phosphepine Oxides

Organic Letters 2026

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Authors: Shaobai Yan, Jin-Ying Shao, Xian-Qi Hu, Xiao-Qin Long, Wei‐Liang Duan
DOI: 10.1021/acs.orglett.6c02431
Cited by: 1
References: 48

Abstract

Asymmetric palladium/norbornene (NBE) cooperative catalysis is a powerful platform for assembling complex molecules. However, achieving enantiocontrol remains a fundamental challenge in cascades where the stereodetermining step occurs strictly after NBE extrusion. We report a conceptually distinct palladium-catalyzed annulation enabled by an exogenous chiral hydroxamic ester. This ligand remains coordinated to the palladium center throughout the catalytic cycle, affording diverse seven-membered P -stereogenic phosphepine oxides in moderate to good yields and up to 92% ee.

Fields of Study & Subjects

Organophosphorus compounds synthesis Asymmetric Hydrogenation and Catalysis Synthesis and characterization of novel inorganic/organometallic compounds

Publication details

Journal / source
Organic Letters
Publisher
American Chemical Society (ACS)
Volume
28
Issue
28
Pages
8982–8987
Publication date
1 July 2026
Language
EN