Rhodium(III)-Catalyzed [3 + 2] Annulation of Diazo Compounds with Enaminones for Constructing Polysubstituted NH-Pyrroles
Abstract
A simple and efficient approach to access polysubstituted NH-pyrroles by a cascade annulation of diazo compounds with β-enaminones has been developed. This transformation proceeds via nucleophilic addition of the enaminones to rhodium carbenoid and subsequential intramolecular annulation, demonstrating a broad substrate scope with good functional group compatibility. Notably, it offers a practical protocol to densely substituted pyrroles bearing NH and carbonyl groups, which can be further diversified through a range of downstream transformations.
Fields of Study & Subjects
Cyclopropane Reaction Mechanisms
Catalytic C–H Functionalization Methods
Synthesis and Reactivity of Heterocycles
Publication details
- Journal / source
- Organic Letters
- Publisher
- American Chemical Society (ACS)
- Volume
- 28
- Issue
- 29
- Pages
- 9343–9348
- Publication date
- 10 July 2026
- Language
- EN