Photoelectrochemical Dehydrogenative Cross-Coupling of Aliphatic C–H Bonds via an In-Situ-Generated Hypervalent Iodine Mediator

Organic Letters 2026

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Authors: F Q Gong, Shao-Hua Wu, Kong De-yi, Ling-Xiang Yu, Rong Wang, Zhu Cao, Qing‐Hai Deng
DOI: 10.1021/acs.orglett.6c02551
Cited by: 1
References: 74

Abstract

A photoelectrochemical strategy is disclosed for the first time that allows for the in-situ generation of hypervalent iodine species I(III) via anodic oxidation, followed by photolytic formation of a trifluoroethoxy radical. This alkoxy radical undergoes hydrogen atom transfer (HAT) with aliphatic C(sp 3 )–H bonds to generate alkyl radicals, which are then captured by various trapping agents. This metal- and chemical-oxidant-free system operates under mild conditions, exhibits broad substrate scope and gram-scale scalability, and expands the utility of aryl iodides in photoelectrochemical synthesis.

Fields of Study & Subjects

Oxidative Organic Chemistry Reactions Radical Photochemical Reactions Catalytic C–H Functionalization Methods

Publication details

Journal / source
Organic Letters
Publisher
American Chemical Society (ACS)
Volume
28
Issue
29
Pages
9443–9449
Publication date
13 July 2026
Language
EN