Visible Light-Induced N -Phenylbenzo[ c ]phenothiazine-Catalyzed α-C(sp 3 )–H Phosphonylation of Secondary Amines via Intramolecular 1,5-HAT

Organic Letters 2026

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Authors: Lipeng Qiao, Zhichao Zhang, Yechun Wu, Kai Sun, Xi Li, Xiaolan Chen, Lingbo Qu, Bing Yu
DOI: 10.1021/acs.orglett.6c02556
Cited by: 6
References: 52

Abstract

We report N -phenylbenzo[ c ]phenothiazine ( PTZ-6 ), an organic small-molecule photocatalyst, which enables a general, metal-free, visible-light-driven Arbuzov-type α-C(sp 3 )–H phosphonylation of diverse cyclic and acyclic secondary amines via an intramolecular 1,5-hydrogen-atom-transfer (HAT) manifold. The protocol exhibits broad functional-group tolerance and is amenable to late-stage modification of structurally complex drugs and bioactive molecules.

Fields of Study & Subjects

Organophosphorus compounds synthesis Radical Photochemical Reactions Catalytic C–H Functionalization Methods

Publication details

Journal / source
Organic Letters
Publisher
American Chemical Society (ACS)
Volume
28
Issue
28
Pages
9077–9082
Publication date
3 July 2026
Language
EN