Nickel-Catalyzed 8-Endo Cyclization/Carbonylation for the Synthesis of Eight-Membered Lactams

Organic Letters 2026 Open access

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Authors: Yibin He, Zilin Huang, Yuting Jiang, Hucheng Ma, Xinxin Qi, Xiao‐Feng Wu
DOI: 10.1021/acs.orglett.6c02643
Cited by: 1
References: 61

Abstract

Medium-sized lactams are prevalent motifs in many bioactive molecules and natural products. However, their construction remains challenging due to unfavorable enthalpic and entropic barriers during the transition state. Herein, a novel nickel-catalyzed 8-endo cyclization/carbonylation has been achieved for the synthesis of eight-membered lactams bearing a gem-difluoro group. This approach features high regioselectivity, good functional group tolerance, and CO gas-free operation, which provides a good supplement for the preparation of eight-membered lactams via a nickel-catalyzed carbonylation process.

Fields of Study & Subjects

Catalytic C–H Functionalization Methods Catalytic Cross-Coupling Reactions Catalytic Alkyne Reactions

Publication details

Journal / source
Organic Letters
Publisher
American Chemical Society (ACS)
Volume
28
Issue
27
Pages
8748–8753
Publication date
29 June 2026
Language
EN