Stretchable and Adhesive SeNPs-Loaded Strong Hydrogel Film with Multifunctional Bioactivity toward Wound Healing

In the field of wound care, the demand for effective materials that combine strong mechanical performance with bioactivity is crucial. This study presents a multifunctional, stretchable, and adhesive hydrogel film composed of carboxymethylcellulose (CMC), punicalagin (PUN), glycerol (GLY), and poly(3,4-ethylenedioxythiophene) polystyrenesulfonate (PEDOT:PSS), specifically designed for advanced wound healing applications. The hydrogel film exhibits high mechanical strength, elasticity, and reliable adhesion, making it suitable for dynamic wound environments. Selenium nanoparticles (SeNPs) were incorporated to enhance the hydrogel's bioactive properties. The SeNP-integrated hydrogel demonstrates antibacterial, antibiofilm, and antifungal activity, along with strong antioxidant capacity that supports cell proliferation. These attributes are essential for accelerating tissue repair, reducing infection, and mitigating oxidative stress, thereby improving the wound healing process. Overall, the SeNP-loaded hydrogel film represents a combination of mechanical robustness, effective adhesion, and multifunctional biological activity, highlighting its potential as a therapeutic platform for wound management.