Functional Performance of Silk Nanoparticles for Oral Drug Delivery
Abstract
intestinal tissue model. Intestine epithelial tight junctions transiently opened after exposure to all particle types and then recovered, suggesting improved permeation of peptide drugs and thus higher bioavailability. SNPs provided high loading efficiency (>80%), sustained release of loaded semaglutide with bioactivity maintained after loading, and exhibited slow degradation under simulated intestinal enzymatic conditions, preserving drug integrity during transit to support oral delivery goals. These findings highlight the potential of SNPs to overcome key GI tract barriers and significantly improve the oral bioavailability of sensitive peptide-based therapeutics.
Fields of Study & Subjects
Silk-based biomaterials and applications
Advanced Drug Delivery Systems
RNA Interference and Gene Delivery
Publication details
- Journal / source
- ACS Applied Materials & Interfaces
- Publisher
- American Chemical Society (ACS)
- Volume
- 18
- Issue
- 22
- Pages
- 31046–31060
- Publication date
- 27 May 2026
- Language
- EN