Association of Non-Bridging Oxygen with Cytocompatibility in Cerium and Cobalt Codoped 58S Bioglass
Abstract
58S-Bioactive glass (bioactive glass (BG)) exhibits exceptional osteointegration (bioactivity), making it highly suitable for applications such as dental implants, bone healing, and tissue regeneration, but lacks antibacterial properties. In the current study, cobalt and cerium are used as potential dopants to stimulate osteoblast-like MG-63 and NIH 3T3 cells, inhibit growth of Escherichia coli and Staphylococcus aureus, while exhibiting enhanced mechanical properties. Doping of Ce and Co into 58S-BG induced structural changes, evidenced by the shift in Si 2p and O 1s spectra to lower binding energy, is associated with an enhanced nonbridging oxygen. Highly dense (∼98%) 2.5Ce5CoBG spark plasma sintered (SPS, crystallinity
Fields of Study & Subjects
Bone Tissue Engineering Materials
Dental Implant Techniques and Outcomes
Advanced ceramic materials synthesis
Publication details
- Journal / source
- ACS Biomaterials Science & Engineering
- Publisher
- American Chemical Society (ACS)
- Volume
- 12
- Issue
- 3
- Pages
- 1474–1491
- Publication date
- 11 February 2026
- Language
- EN