Construction of Peptide Amphiphile-Coated Coacervates with Selective Permeability

The combination of membranes with coacervates has been regarded as an effective approach to stabilize coacervates and modify their surface properties. Here, we achieved the construction of a functional coacervate system by localizing nanovesicles assembled by elastin-like peptide-block-collagen-like peptides (ELP-CLPs) on the surface of polyelectrolyte coacervates. The formation of the ELP-CLP coating was driven by electrostatic interactions between negatively charged ELP-CLP vesicles and positively charged coacervates. Altering the surface charge of ELP-CLP vesicles or coacervates disrupted the formation of coatings, and the formulation parameters, such as different mixing protocols and the order of adding the components, could be used to control the coating process. The ELP-CLP vesicle coating successfully functionalized the coacervates and presented the ability to control the diffusion of molecules based on their different molecular weights. Our results demonstrated approaches to control the coating process and coating functionality of ELP-CLP vesicle coatings and highlighted their potential application as a novel surface modification to provide selective permeability to current coacervate systems.