Electrophotochemical Decarboxylative C−H Fluoroalkylation via a Fe 2 O 3 −FTO Active Photoanode

ACS Catalysis 2026 Open access

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Authors: Vladimir Motornov, Zhi Liu, Kentaro Imaoka, Sven Trienes, H. Kang, R. Thomas Weitz, Prof. Dr. Lutz Ackermann
DOI: 10.1021/acscatal.5c07973
Cited by: 2
References: 38

Abstract

High Resolution Image Download MS PowerPoint Slide C−H fluoroalkylation of heteroarenes and biomolecules employing inexpensive carboxylic acids based on electrophotochemical oxidation on a Fe 2 O 3 photoanode was developed. Notably, the devised approach proved amenable to a wide range of versatile late-stage C−H fluoroalkylations of biorelevant heterocycles. Mechanistic studies supported a direct electron transfer to form a fluoroalkyl radical with a cost-efficient heterogeneous iron catalyst.

Fields of Study & Subjects

Fluorine in Organic Chemistry Radical Photochemical Reactions Porphyrin Metabolism and Disorders

Publication details

Journal / source
ACS Catalysis
Publisher
American Chemical Society (ACS)
Volume
16
Issue
7
Pages
6380–6386
Publication date
12 March 2026
Language
EN