Organophotoredox/Cobalt-Catalyzed Hydrocarboxylation of Propargyl Amides Using CO 2 and H 2 O
Abstract
CO 2 and H 2 O are abundant small molecules in nature. However, the concomitant use of these compounds for catalytic carbon–carbon bond formation is limited. Here, we report the photoredox/cobalt dual-catalyzed syn -selective hydrocarboxylation of propargyl amides employing CO 2 and H 2 O as reagents without relying on conventional chemical hydride equivalents (dialkyl zinc or hydrosilanes). This method provides β 2 -amino acid and α,β 2 -peptide precursors with up to 20:1 regioselectivity, thus circumventing the hazardous catalytic hydrocyanation–hydrolysis protocol.
Fields of Study & Subjects
Carbon dioxide utilization in catalysis
Radical Photochemical Reactions
Catalytic C–H Functionalization Methods
Publication details
- Journal / source
- ACS Catalysis
- Publisher
- American Chemical Society (ACS)
- Volume
- 16
- Issue
- 3
- Pages
- 1936–1943
- Publication date
- 16 January 2026
- Language
- EN