Aryl Halide-Driven Nickel Photocatalytic Decarboxylative Elimination
Abstract
High Resolution Image Download MS PowerPoint Slide Nickel photoredox catalytic reactions have found ample application in cross-coupling. However, understanding its mechanistic behavior might identify a bifurcation point, thus allowing for divergent reactivity. In this work, we describe a nickel photoredox decarboxylative β-hydride elimination reaction. Structural-activity analysis of aryl halide additives allowed for tunability, and mechanistic investigations confirm a rate-determining nickel-catalyzed β-hydride elimination step. A consecutive two-photon process yields ( Z )-enamides from a combination of decarboxylative elimination and Dexter energy transfer from the same iridium photocatalyst.
Fields of Study & Subjects
Radical Photochemical Reactions
Catalytic C–H Functionalization Methods
Catalytic Cross-Coupling Reactions
Publication details
- Journal / source
- ACS Catalysis
- Publisher
- American Chemical Society (ACS)
- Volume
- 16
- Issue
- 5
- Pages
- 5105–5114
- Publication date
- 22 February 2026
- Language
- EN