Chlorination of Amines by a Vanadium-Dependent Chloroperoxidase
Abstract
High Resolution Image Download MS PowerPoint Slide Organic chloramines are an important class of compounds containing a covalent nitrogen–chlorine bond. Despite the growing interest in their applications in small molecule synthesis and polymer science, selective catalyst systems for their preparation have remained elusive. We recently discovered that the vanadium-dependent chloroperoxidase from Curvularia inaequalis ( Ci VCPO) is an effective biocatalyst for selective chlorination of a broad range of structurally diverse amines to give the corresponding chloramines and chlorimines. The catalyst system is readily scalable and applied to chemoenzymatic nitrile and amide synthesis. Finally, halide divergent reactivity is demonstrated through chloride-selective chlorimine formation and bromide-selective aldehyde formation using the same biocatalyst.
Fields of Study & Subjects
Vanadium and Halogenation Chemistry
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Publication details
- Journal / source
- ACS Catalysis
- Publisher
- American Chemical Society (ACS)
- Volume
- 16
- Issue
- 7
- Pages
- 6241–6246
- Publication date
- 23 March 2026
- Language
- EN