Stirring the Debate: How Mixing Influences Reproducibility and Efficiency in Synthetic Organic Chemistry

ACS Central Science 2026 Open access

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Authors: Jasper H. A. Schuurmans, Stefan D. A. Zondag, Arnab Chaudhuri, John Van der Schaaf, Timothy Noël
DOI: 10.1021/acscentsci.5c01825
Cited by: 15
References: 60

Abstract

Mixing is essential in chemical processes, ensuring the proximity and interaction of reactants. Recent reports suggest stirring may minimally affect some solution-phase organic reactions, but this oversimplifies mixing's complexity. We discuss its principles, relevance to organic synthesis, and practical considerations for reproducibility and safety. Even if some reactions seem agitation-insensitive, mixing remains crucial for reproducibility, scalability, and industrial applications.

Fields of Study & Subjects

Innovative Microfluidic and Catalytic Techniques Innovation Cyclization and Aryne Chemistry Chemical Synthesis and Analysis

Publication details

Journal / source
ACS Central Science
Publisher
American Chemical Society (ACS)
Volume
12
Issue
1
Pages
7–13
Publication date
6 January 2026
Language
EN